TFPI and cardiovascular disorder: We therefore measured endogenous levels of TF activity, as well as plasma levels of Factors II, V, VII, VIII, IX, and X and activities of two key inhibitors, Tissue Factor Pathway Inhibitor (TFPI) and Antithrombin (AT), in the plasma of 162 patients who suffered an MI under 50 years and 186 healthy subjects matched for age, gender, and smoking status, with no history of cardiovascular disease (30).