MRPS21 and heart failure: To further validate this finding, the associations between the DEMRGs and HF were examined in the GSE135055 dataset, which demonstrated that the seven DEMRGs including MRPS21, STRN, FN1, NET1, FZD7, MYH10, and TBL1XR1 were all highly expressed in patients with heart failure and may act as diagnostic biomarkers for HF patients as well (Figures 6E,F).