Genetic research has found that ARVC is associated with gene mutations of cell junctions, especially the mutations in genes encoding desmosome components, including plakoglobin (JUP), desmoplakin (DSP), plakophilin2 (PKP2), desmoglein2 (DSG2), and desmocollin2 (DSC2) (4). The gene discussed is DSP; the disease is arrhythmogenic right ventricular cardiomyopathy.