CRP and systemic sclerosis: This study showed that in SSc patients without a diagnosis of APAH: (1) at rest, PAPs values are positively correlated with sympathetic- and negatively correlated with vagal-mediated indexes of symbolic HRV analysis; (2) higher PAPs values are correlated to a blunted cardiac autonomic responses at active standing test (i.e., reduced Δ0V% and increased Δ2LV% and 2LV; (3) the +PAPs group presented higher CRP values (attributable to a low-grade inflammation) and a blunted cardiac autonomic modulation compared to the –PAPs group.