As compared with control subjects (13.01 ± 8.53 mg/min × Kg FFM), both T2DM MetS (3.06 ± 1.7 mg/min × Kg FFM, P = 0.008) and T2DM Non-MetS (2.91 ± 1.54 mg/min × Kg FFM, P = 0.01) exhibited a significant reduction in insulin-stimulated glucose disposal after adjusting for age and gender (Table 2). The gene discussed is INS; the disease is type 2 diabetes mellitus.