Type 2 DM mice (C57BLKS/J Lepr (db)/Lepr (db) mice and BKS.Cg-m+/+Lepr(db)/J mice) were used to investigate LEPR effects on cardiomyocyte function and ventricular arrhythmias after MI and after developing diabetes (41, 42). This evidence concerns the gene LEPR and diabetes mellitus.