After validation using GEO datasets and MI mice model, the 10 hub genes, such as IL-6, PTGS2, JUN, NQO1, NOS3, LEPR, NAMPT, CDKN2A, CDKN1A, and Snai1, can be the diagnostic ferroptosis- and autophagy-related targets and biomarkers in MI deterioration and can be targets to prevent adverse cardiac events. Here, PTGS2 is linked to myocardial infarction.