Nrf2, NQO1, and HO-1, as antioxidative molecules, were always used as biomarkers to detect the drug effects on MI and Parkinson’s disease (36, 37), for instance, cytoplasm HO-1, cytoplasm NQO1, and nucleus Nrf2 expressions increased both in vivo and in vitro using azafrin after MI. The gene discussed is HMOX1; the disease is Parkinson disease.