TP53 and myocardial infarction: In these studies, associations were established for TP53 mutations with smoking (32% vs 15%, P = 0.10) [13] and cardiovascular disease (HR: 25.8, 95% CI: 1.96‐340.5, P = .013) [13] as well as DNMT3A mutations with a history of myocardial infarction (14% vs 6%, P = .03) [14].