CD20 negative (CD20‐) DLBCL is rare and includes sub‐types such as primary effusion lymphoma, plasmablastic lymphoma, ALK+ large B‐cell lymphoma (ALK+LBCL), and large B‐cell lymphoma arising in HHV8+ multicentric Castleman disease (HHV8+ MCD).[3] Association with HIV, HHV‐8, and EBV has been noted in most subtypes with the exception of ALK+LBCL.[4] Survival except with HHV8+ MCD, is reported to be worse than DLBCL‐NOS (not otherwise specified).[3]. This evidence concerns the gene MS4A1 and diffuse large B-cell lymphoma.