After multiple screenings, a total of 10 hub genes related to NASH (KDR, FYN, RAC1, MAPK1, ERBB2, CDKN1A, HSPA4, SMAD2, MCL1, and ESR1) in the circRNA–miRNA–mRNA network were identified. The gene discussed is ESR1; the disease is metabolic dysfunction-associated steatohepatitis.