Then, a subnetwork with 10 nodes and 31 edges was selected, which revealed the critical roles of the ten genes (KDR, FYN, RAC1, MAPK1, ERBB2, CDKN1A, HSPA4, SMAD2, MCL1, and ESR1) in NASH (Figure 6). Here, ESR1 is linked to metabolic dysfunction-associated steatohepatitis.