Furthermore, METTL3 has been shown to promote Ang II- and CaCl2-induced abdominal aortic aneurysm by accelerating primary microRNA-34a maturation and inhibiting SIRT1 expression 33, and METTL3 also exacerbates oscillatory stress-induced atherogenesis 38. The gene discussed is AGT; the disease is abdominal aortic aneurysm.