In the present study, we found that SLC7A11, FSP1 and GPX4, key regulators of ferroptosis, were downregulated in the aortas of Stanford type A AD (TAAD) patients, and inhibition of ferroptosis by liproxstatin-1 largely abrogated β-aminopropionitrile (BAPN)-induced AD in mice. The gene discussed is GPX4; the disease is Alzheimer disease.