Furthermore, METTL3 has been shown to promote Ang II- and CaCl2-induced abdominal aortic aneurysm by accelerating primary microRNA-34a maturation and inhibiting SIRT1 expression 33, and METTL3 also exacerbates oscillatory stress-induced atherogenesis 38. This evidence concerns the gene SIRT1 and abdominal aortic aneurysm.