Since SLC7A11, FSP1 and GPX4 were decreased, while METTL3 was elevated in the aortic walls of patients with TAAD, we were very curious about whether METTL3, SLC7A11, FSP1 and GPX4 can form a pathway to participate in the regulation of the pathological process of AD. The gene discussed is AIFM2; the disease is Alzheimer disease.