To analyze the function of RNA m6A methylation in SLC7A11, FSP1 and GPX4 expression regulation and AD, we first detected the expression of m6A modulators, including m6A demethylases (AlkB homolog 5 (ALKBH5) and fat mass and obesity-associated protein (FTO)) and subunits of the methyltransferase complex (Wilms' tumor 1-associated protein (WTAP), METTL14, and METTL3), in a small cohort consisting of 12 non-AD and 28 TAAD aortic tissues. Here, ALKBH5 is linked to Alzheimer disease.