Song et al. found that METTL3 inhibited autophagic flux in hypoxia/reoxygenation (H/R)-treated cardiomyocytes 18, while Liu et al. demonstrated that METTL3 positively regulated autophagy by promoting the expression of autophagy related 5 (ATG5) and ATG7 in non-small cell lung cancer (NSCLC) cells 17. This evidence concerns the gene ATG7 and non-small cell lung carcinoma.