AKR1A1 and neoplasm: A Fungi-based acetaldehyde generator was prepared by modifying alcohol dehydrogenase-loaded metal-organic framework nanocarriers onto the surface of Saccharomyces cerevisiae (S. cerevisiae), which can target the TAMs by mannose, induce tumor cell apoptosis and promote TAMs polarization to anti-tumor phenotype, and further enhance macrophage-mediated immunotherapy by combining anti-CD47 antibody, significantly inhibit the growth of CRC cell 170.