The key interactome-related nodal point for molecular drivers of AF progression is dealing with systems associated with Ca2+/calmodulin-dependent protein kinase-II (CaMKII) and NACHT, LRR, and PYD domain-containing protein 3 (NLRP3), where the intracellular processes related to triggers result from focal ectopic firing and inflammatory signaling 3-6. Here, NLRP3 is linked to atrial fibrillation.