USP22 and non-small cell lung carcinoma: Consistent with our finding, circFAT1 was reported to be upregulated in five NSCLC patients tested, although we found that the reported target miR-30e-5p was reduced by 51% and USP22 mRNA did not change significantly in A549 cells upon shcircFAT1 treatment, instead of an increase of miR-30e-5p by about 4 fold and a reduction of USP22 by half in the report 36.