To ascertain which transcription factor indeed plays a key role in the mesenchymal pancreatic cancer cells ferroptosis, we firstly analyzed the patients' data in GEPIA database (https://gepia.cancer-pku.cn/index.html) and identified that ZEB1 (Figure 3B), rather than Twist, Snail, and Snai2 (Figure S3A), are highly correlated with O-GlcNAcylation critically associated genes (GFPT1 and OGT). This evidence concerns the gene TWIST1 and familial pancreatic carcinoma.