RASAL2 also suppresses cancer progression via the RAS-ERK pathway 22, phosphoinositide 3-kinase (PI3K)/AKT/mechanistic target of rapamycin (mTOR) signaling pathway 7, nuclear factor (NF)-κB pathway 7, and ERK/mitogen activated protein kinase (MAPK) pathway 8. This evidence concerns the gene WNK2 and cancer.