ASPG and pancreatitis: As pancreatitis may be diagnosed in several ways including through (1) clinical signs/symptoms (abdominal pain, emesis, nausea, back pain, fever), (2) laboratory based studies (amylase and/or lipase >3 times upper limit of normal), and (3) radiological imaging (ultrasound, CT, or MRI) an internationally agreed upon definition has been established stating two of these three characteristics must be present in order to diagnose asparaginase-associated pancreatitis (62).