Genomic analysis based on a NGS panel (Oncomine Childhood Cancer Research Assay) detected a <i>RBM15::MKL1</i> fusion, a consequence of a <i>t</i> (1;22)(p13;q13) translocation, establishing the diagnosis of acute megakaryoblastic leukemia and enabling disease follow-up by qPCR. Here, MRTFA is linked to acute megakaryoblastic leukemia.