As noted above, ARF6 was identified as a susceptibility gene for BA and now, these findings with MAN1A2, suggest that MAN1A2 can affect ciliary development and EGFR signaling and regulate the formation of intrahepatic biliary networks by interacting with ARF6. However, to date, no variants in this gene have been found. This evidence concerns the gene ARF6 and breast angiosarcoma.