ARF6 and breast angiosarcoma: It is also widely believed that genetic factors play an important role, as several genes have been identified to be associated with BA, including ADD3, EFEMP1, MMP7, and ARF6. With the development of GWAS, a number of Copy Number Variations (CNVs) and Single Nucleotide Polymorphisms (SNPs) have been observed in BA and was highly associated with the pathogenesis of BA.