The first indication that the SNP (rs3746444) in MIR499 (MicroRNA-499) was of relevance to BA and correlates with the increased expressions of inflammatory factors (IL-6, TNF-α) in the serum and liver of BA patients was presented in 2016 by Shan et al. The G allele of rs3746444 was related with the degree of inflammation. The gene discussed is IL6; the disease is breast angiosarcoma.