RUNX1 and acute myeloid leukemia: Germline nonsense and missense mutation were respectively detected in three patients with AML, five of which acquired a somatic DDX41 mutation (4 R525H, 1 T227M), the remaining one concomitant with five somatic gene mutations (CSF3R, IDH2, RUNX1, SH2B3, WT1) (Figure 1B).