Mutation in DNA (cytosine‐5)‐methyltransferase 3 alpha (DNMT3A), a gene involved in epigenetic regulation via DNA methylation, is associated with both MDS/MPN‐RS‐T and myelodysplasia with RSs (MDS‐RS) [63]. This evidence concerns the gene DNMT3A and myeloproliferative neoplasm.