‐Most common: ASXL1, TET2, SRSF2, NRAS, EZH2, RUNX1, CBL‐Most specific: SETBP1, ETNK1‐CSF3R more common in CNL than aCML‐High risk mutations:‐SETBP1, ASXL1, CBL, TET2. This evidence concerns the gene CBL and chronic neutrophilic leukemia.