As SETBP1 has a lower prevalence in other MDS/MPN except CMML or CNL, and ETNK1 is only otherwise seen in CMML and systemic mastocytosis [43], these genetic markers can be useful to distinguish aCML from other myeloid neoplasms. This evidence concerns the gene ETNK1 and atypical chronic myeloid leukemia, BCR-ABL1 negative.