GPT and Hyperglycemia: Specific grade 3 of 4 AEs observed in the patients enrolled on CALGB 10403 included hyperglycemia (31%), alanine transaminase elevation (29%), febrile neutropenia (24%), hyperbilirubinemia (19%), aspartate transaminase elevation (13%), and thrombosis (5%) with a TRM of 2% during induction.