CXCR3 and neoplasm: In subcutaneous and pulmonary mouse tumor models (RMA-S, a lymphoma tumor cell line expressing low levels of class I MHC; B16 melanoma cell line transduced to express the NKG2D ligand RAE-1ε; and pulmonary tumor cell line 3LL-Luc2), decreased intra-tumoral NK cells are observed in Cxcr3-/- mice and in mice treated with anti-CXCR3 antibodies; but despite this, no difference in survival is observed (65, 126).