KLRK1 and neoplasm: For example, MMPs and A disintegrin and metalloproteinases (ADAMs), which are often present in the TME (172) and the post-viral lung (173), cleave NKG2D ligands (NKG2DLs) from the cell surface of tumor cells or infected cells, which leads to the evasion of NK cell-mediated killing (114, 174–176).