All of these four identified biomarkers, SIGLEC9, TSPO, CKS1B, and PTTG3P, were remarkably upregulated in the sepsis and se-ARDS group compared with the control group (P<0.05, except for CKS1B in se-ARDS group), whereas no remarkable changes were shown in the se-ARDS group compared with the sepsis groups (P>0.05). The gene discussed is CKS1B; the disease is Sepsis.