In this study, we describe that T cell itself can metabolize vitamin A into RAL by RDH10, a rate-limiting enzyme for RA biosynthesis, and that lack of the vitamin A metabolism by T-cell-specific Rdh10 knockout enhances the induction of memory, especially, central memory T cells (TCM) in Listeria infection model, indicating that vitamin A metabolites such as RAL and RA regulate T cell differentiation. The gene discussed is RDH10; the disease is listeriosis.