CD4 and neoplasm: Although the higher proportion of immunosuppressive cells (e.g., Tregs and monocytes) and lower proportion of immunity boosting cells (e.g., naive B cells, activated CD4 memory T cells and activated NK cells) observed did not reach significance in the tumors with CCND1 amplification versus controls, these results indicated that CCND1 amplification promoted an immunosuppressive tendency in tumor microenvironment and consistent with the findings of our bioinformatic analysis.