HIF1A and cancer: Secondly, HIF1A, VEGFs, angiopoietin growth factors, MET, HGF, PDGFs and FGF2/FGFR2 are TME-related molecules (49) and previous studies had revealed that cyclin D1 may play a key role in the maintenance of VEGFs, and antisense to cyclin D1 could be useful for targeting both cancer cells and blood vessels in tumor (50), we analyzed the RNA-Seq data in TCGA focusing on above-mentioned single genes.