In contrast to our previous findings in a TCGA pan-cancer cohort (33), patients with melanoma in the CCND1 High Amplification group in the present study showed downregulation of many genes associated with angiogenesis (HIF1A, VEGFs, VEGFRs, FGFs, and FGFRs) (Figure 5C). The gene discussed is HIF1A; the disease is cancer.