In contrast to our previous findings in a TCGA pan-cancer cohort (33), patients with melanoma in the CCND1 High Amplification group in the present study showed downregulation of many genes associated with angiogenesis (HIF1A, VEGFs, VEGFRs, FGFs, and FGFRs) (Figure 5C). This evidence concerns the gene CCND1 and melanoma.