IFNA1 and viral infectious disease: The recurrent appearance of IFN genes and ISGs highlights its importance in AIDS immunopathogenesis, as the generic immune response to viral infection with OAS and MX genes, or genes specifically involved in HIV infection as IFI27. In contrast, in viremic non-progressors lower expression of ISG is found when compared to TPs (46) pointing to a mechanism of viral tolerance instead of the increased and efficient IFN response observed in LTNPs and HIC patients.