Considering that IL-6 can impair NK cell functions and that elevated level of IL-6 is a key feature of severe SARS-CoV-2 infection (51), clinical trials aiming to disclose the efficacy of drugs inhibiting IL-6 signaling are ongoing [review in (115)] and promising results deriving from the use of Tocilizumab, a humanized monoclonal antibody against IL-6 receptor, support the hypothesis that IL-6 axis represents a possible therapeutic target to treat severe COVID-19 patients by promoting NK cell functionality (33, 116). This evidence concerns the gene IL6 and COVID-19.