As shown in Figures 2A–M, CENPL may act as a perfect diagnostic marker in BLCA (AUC = 0.914), BRCA (AUC = 0.955), CAOD (AUC = 0.858), ESCA (AUC = 0.975), GBM (AUC = 0.999), glioma (GBMLGG; AUC = 0.887), HNSC (AUC = 0.922), LIHC (AUC = 0.952), LUAD (AUC = 0.952), LUSC (AUC = 0.993), STAD (AUC = 0.921), stomach and esophageal carcinoma (STES; AUC = 0.938), and UCEC (AUC = 0.968). Here, CENPL is linked to central nervous system cancer.