1) PKM2 expression is highly expressed in monocytes, DCs, and B cells derived from patients with SLE, compared to those derived from healthy volunteers. A PKM2-MAPK/NF-κB-PKM2 feedback loop is activated in these cells in spontaneous lupus MRL/lpr mice and imiquimod-induced lupus mice. Here, PKM is linked to systemic lupus erythematosus.