1) The expression of GLUT-3 and GLUT-6 is decreased on the cell membranes of neutrophils in patients with SLE.2) Deficiency of PPP leads to reduced NOX2 activity and ROS production. Reduced cellular redox capacity and oxidation of mitochondrial DNA initials NETs and neutrophil death. This evidence concerns the gene CYBB and systemic lupus erythematosus.