CDKN2A and ependymoma: Interestingly, genetic and epigenetic changes associated with cytotoxic treatments have also been reported for non-hematologic malignancies, such as pediatric ependymomas manifesting as SPMs, which depict hypermethylated phenotype leading to loss of tumor suppressor genes, such as CDKN2A, CDKN2B and p14ARF (59–61).