IL4 and neoplasm: On the other hand, in response to other cytokines such as interleukin-4 (IL-4) and IL-13, macrophages are polarized into M2 subtype that produces anti-inflammatory factors such as arginase 1, IL-10, and TGF-β, participating in angiogenesis and forming immunosuppressive microenvironment to lead to tumor growth, progression and metastasis.