The transcriptome of SARS-Cov-2 M protein-reactive CD4+ TCLs revealed pathways associated with a diverse list of inflammatory diseases and functions, including the top 3: viral infection (107 overlapping molecules, p=7.0-33), systemic autoimmune syndrome (86 overlapping molecules, p=1.3-28), and most strikingly, Severe COVID-19 (31 overlapping molecules, p=6.8-28) (Figure 5B). This evidence concerns the gene CD4 and COVID-19.