In addition to the direct cytotoxic activity of the granules containing MBP on tumor cells (74, 75), eosinophils in tumor microenvironment (TME), when activated by interferon (IFN)-γ and tumor necrosis factor (TNF)-α efficiently promote mobilization of CD8+ cytotoxic T cells from circulation (76). The gene discussed is CD8A; the disease is neoplasm.