PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Hypermethylation of CpG99 in the regulatory region of the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene and hypomethylation of CpG26 in the regulatory region of the parvin beta 1 (PARVB1) gene have been associated with advanced hepatic fibrosis in patients with NAFLD (220) (Table 4).