Two generations of offspring from male rats with a history of liver fibrosis have inherited a resistance to hepatic fibrosis manifested by impaired differentiation of hepatic myofibroblasts, increased expression of the anti-fibrotic peroxisome proliferator-activated receptor-gamma (PPAR-γ) protein, and decreased production of the pro-fibrotic transforming growth factor beta 1 (TGF-β1) cytokine (182). The gene discussed is TGFB1; the disease is Hepatic fibrosis.