RNF115 and infection: However, interestingly, infections with the DNA virus herpes simplex virus 1 (HSV-1) and transfection of dsDNA fail to upregulate or maintain the RNF115 protein or Rnf115 mRNA in the presence or absence of Actinomycin D or CHX (25), indicating distinct transcriptional and post-transcriptional regulatory mechanisms of RNF115 by RNA and DNA viruses that require further investigations.