RNF115 which is also known as Rabing7 (Rab7-interacting RING finger protein), BCA2 (breast cancer-associated gene 2) and ZNF364 (Zinc finger domain-containing protein 364) belongs to the RING finger family and functions independent of the CRL system to catalyze polyubiquitination of various substrates (14, 15). Here, RNF115 is linked to cancer.