TNF and systemic lupus erythematosus: KEGG pathway analysis of the intestinal tissue after P. shigelloides challenge revealed that there were 21 KEGG metabolic pathways involving different genes, mainly including the complement and coagulation cascade pathway, TNF signaling pathway, interleukin (IL)-17 signaling pathway, and toxoplasmosis and systemic lupus erythematosus pathway (Figure S2B).