In contrast to what was observed for IFN-α, the release of IL-1α and TGF-β from PBMCs collected by PC patients who showed signs of lung fibrosis, after cytosolic dsDNA stimulation, was neither associated with caspase-1 nor caspase-4-dependent AIM2 inflammasome activation or to the cGAS-STING pathway. The gene discussed is CASP1; the disease is pachyonychia congenita.