NLRP3 and pachyonychia congenita: Based on the similarities in terms of GGO observed at the chest CT scan and other common features of fibrosis between PC syndrome and IPF (6–8), we could speculate that as we observed for IPF (9), NLRP3 is not involved, but rather the stimulation of AIM2 in circulating monocytes could be involved in lung fibrosis-like changes in PC patients.