However, the effect of ADAM10 appeared to depend on the antibody profile, because ADAM10 inhibition was not protective in both the cell culture and ex vivo pemphigus skin models, when a PV-IgG from a different patient (PV4-IgG), containing high levels of anti-Dsg1 autoantibodies was used. The gene discussed is ADAM10; the disease is pemphigus.