In response to damage or some types of infections, eosinophils are recruited to sites of inflammation where they secrete cytokines such as IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IL- 16, IL-18, TGF, toxic granular proteins, lipid mediators, in addition to being capable of inducing tissue damage and dysfunction (29). This evidence concerns the gene IL18 and infection.