In obesity, not only the nutritional status of the individual changes, but also concentrations of messenger molecules, such as leptin, adiponectin, resistin, visfatin, and others, which may directly affect Th2 cell function or indirectly inhibit Th2 cells by promoting Th1/Th17-biased inflammation. Here, NAMPT is linked to obesity due to melanocortin 4 receptor deficiency.