More recently, a meta-analysis of genome-wide association studies in humans identified GSDMA and GSDMB variants associated with systemic sclerosis (7): macrophages from patients with systemic sclerosis who carried the risk variant rs3894194 showed GSDMA over-expression (71), but clear links between the functions of these less well-studied GSDMs and the pathophysiology of the disease remain to be elucidated. The gene discussed is GSDMA; the disease is systemic sclerosis.