CASP3 and cancer: Some conventional chemotherapeutic drugs, such as cisplatin and doxorubicin, also cause pyroptosis in cancer cell lines by activating the caspase-3-GSDME pathway (12, 93); while micro-RNA-mediated reactivation of GSMDE expression, in combination with cetuximab, effectively induced pyroptosis of tumor cells and reduced tumor volume in a mouse model of aggressive triple-negative breast cancer (17).