A recent pan-cancer analysis more comprehensively examined patterns of GSDM expression and assessed their relationship with key immune parameters in tumors: the most striking finding marked GSDMD overexpression in many cancer types, including gastric, colon adenocarcinoma, and breast cancers, which – in contrast to the negative correlations with GSDMB in breast cancer – was associated with increased numbers of potentially beneficial tumor-infiltrating CD8+ T cells, M1 macrophages, and NK cells (82). Here, GSDMD is linked to neoplasm.