ERBB2 and breast carcinoma: In the case of breast cancer, we understand a little more of the possible role of GSDMB: high GSDMB expression in tumor cells from patients with ERBB2-positive breast cancer correlates with poor prognosis, increased risk of metastasis and decreased survival (85), which may be linked to earlier in vitro observations of increased invasiveness and metastatic ability of GSDMB overexpressing immortalized MCF7 tumor cells (9).