A recent study revealed the changes in ADA2 activity that may contribute to the differentiation of macrophages into an unfavorable protumor M2 phenotype in triple-negative breast cancer (84).Together, these findings indicated that the genes that make up the MRGPI are involved in several metabolic activities, and most of the genes are related to tumor progression and prognosis. The gene discussed is ADA2; the disease is triple-negative breast carcinoma.