SFTPA1 and infection: Previously, we observed 1) improved survival after treatment of SP-A-KO infected mice with SP-A, and this was independent of the time of protein treatment, i.e., prior, after, or at the same time as the infection (44); and 2) a significant change in the AM miRNome and AM gene expression profile after exposure to various insults (i.e., ozone or infection) in mice that were constitutively/chronically exposed to SP-A2 (42, 53, 56).