E2F1 and infection: The overwhelming majority of changed miRNAs were downregulated after infection and infection plus SP-A2 (1A0) protein rescue, and these were predicted to target genes that play a role in cell cycle and growth and proliferation pathways, such as CCND1, CCND2, CDK7, CDKN2A, E2F1, E2F2, E2F3, and MYC (Table 1).