APP and Sepsis: Differences between sepsis and controls reached a statistical significance in either cohort separately and/or the pooled training and validation cohorts for a total of ten genes, including higher levels in sepsis for the endo-lysosomal genes APP, CDK5, GUSB, LAIR1, and SGSH. The second study compared Gram-positive, Gram-negative, and mixed sepsis to ICU controls (25).