Figure 2B summarizes the results for the 31 validated DEGs and identifies the respective selection strategy. All but ADGRE3, LINC02289, and PRKDC, showed higher mean expression in sepsis than SIRS, ranging from 2.7-fold (ANLN) to 21.6-fold (SLAMF7). Figure 2C compares signal intensity distributions for the 13 validated DEGs with endo-lysosomal associations and Supplementary Figure S3 for the remaining 18 validated DEGs. Figure 2D revisits the discovery set microarray results for validated DEGs. Here, ADGRE3 is linked to systemic inflammatory response syndrome.