NLRP3 and atherosclerosis: demonstrated that NLRP3 knockdown inhibited the expression of adhesion molecules ICAM-1 and VCAM-1 in intima, reduced atherosclerosis and stabilized atherosclerotic plaques.In vitro, high glucose in HUVECs enhances the expression of NLRP3 inflammasome components and secretion of IL-1β.In addition, high glucose or IL-1β promotes the expression of adhesion molecules that are inhibited by NLRP3 knockdown or IL-1β receptor antagonists (60).