IFNA1 and COVID-19: Gene mutations of the type interferon (IFN) pathway (10) and antibodies to type IFNs play a clear role in a small proportion of cases (11); polymorphisms in several genes associated with immune response have been identified in genome-wide association studies (12, 13); however, to date, the genotypes that convey a risk of severe COVID-19 have not been defined in a way that is practically applicable for prediction in clinical practice.