IL2 and neoplasm: Chemokine signaling, Interleukin2-Signal Transducer and Activator of Transcription 5 (IL2-STAT5) signaling, TNF-A signaling via NF-κB and leukocyte transendothelial migration were also found to be enriched in down-trend patterns, further suggesting an impaired immune function in tumor microenvironment.