RB1 and neoplasm: For individual tumor suppressor genes, frequency of TP53 mutations was found to be significantly higher in LUAD and solid nodules (p < 0.001 and p < 0.001, respectively, Figures 2B, C and Supplementary Tables 1, 2), whereas frequency of RB1 mutations was significantly higher in solid nodules (p = 0.038) and marginally significantly higher in LUAD (p = 0.058).