These tightly regulated STAT signaling control mechanisms can be disrupted in cancer cells, altering an otherwise finely-tuned homeostatic balance, which also occurs in GI cancers including Oral Squamous Cell Carcinoma (OSCC) (59), which comes under umbrella term of Head and Neck Squamous Cell Carcinomas (HNSCC) and Gastric Cancer (GC) (37, 60). The gene discussed is SOAT1; the disease is head and neck squamous cell carcinoma.