GC in Nfkb1-/- mice mimics the histopathology of the human disease and is associated with elevated STAT1, and to a lesser extent STAT3, in the gastric mucosa (208), recapitulating the pathogenic loss-of-function polymorphisms in NF-κB1 associated with human GC (207, 214). The gene discussed is STAT3; the disease is gastric cancer.