Nuclear and cytoplasmic interactions between EGFR and STAT3, increase the expression of several EMT promotors (iNOS, cyclin D1, c-fos) through direct binding of the EGFR/STAT3 complex to their promoters [reviewed (141)] resulting in consistent JAK-STAT triggering in HNSCC (4) (Figure 3A). The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.