For example, chronic STAT3 signaling by cytokines such as IL-6 in transformed cancer cells can induce cell proliferation and activation of MMP’s (matrix metalloproteinases), thereby promoting tumor invasiveness and EMT (epithelia-to-mesenchymal transition) and expression of “master” EMT transcription factors including Twist and Snail (70). This evidence concerns the gene STAT3 and neoplasm.