Multiple studies including the Cancer Genome Atlas Research Network (77), in addition to the risk factors described above, have revealed certain genetic alterations and/or mutations can contribute to GC pathogenesis including; PIK3CA, TP53, KRAS, APC, STK11, CTNNB1, CDKN2A, ARID1A, ERBB2, FGFR1, FGFR2, EGFR and MET and (Figure 3B) (77). Here, ERBB2 is linked to gastric cancer.