PDCD10 and cerebral cavernous malformation: The loss of function (LOF) mutations of CCM1 (KRIT1, Krev interaction trapped protein 1) (23–27), CCM2 (MGC6407, encoding a protein named malcavernin) (28–33), and CCM3 (PDCD10, Programmed cell death protein 10) (34–36) have been thought to be the culprits of familial CCM.