NFKB1 and liver disorder: Moreover, butyric acid produced by Clostridium butyricum can effectively constrain the transfer of nuclear factor kappa B (NF-κB) into the nucleus while repressing the binding of NF-κB and DNA, thus restraining gene expression of a series of proinflammatory factors such as TNF-α and exerting effective effects on the treatment of liver disease [38].